Hereditary/Familial Ovarian Cancer: Testing Principles and Risk Management

Although BRCA1 and BRCA2 pathogenic or likely variants are a well-established cause of hereditary ovarian cancer, recent studies have brought other homologous recombination repair pathway genes into the limelight. The current NCCN Guidelines reflect most up-to-date, evidence-based data relating to risk management patients who carriers BRCA1/2 and/or variants. Risk-reducing bilateral salpingo-oophorectomy is standard care, but recommendation for salpingectomy alone may be on horizon.